Statler and Waldorf vs. Mystery Science Theater 3000. Add in Nelson Muntz and you'd have a traditional Heckler Standoff. Not sure where the picture originated from, but there is a head-spinning debate on reddit about the placement of the MST3K crew. (Link via Unreality)
Previously on Popped Culture...
Muppets Tip When Somebody Deserves A Tip
A Clockwork Green
Muppets Last Supper
